As an added i suggest you don't add a single add on or mod, turn off any guest permissions and the who's online, are you going to set that many usergroups for that many forums?
Also make sure you dont have two lots of gzip running, if its running on your server then you dont need it turned on in your forum, i had issues early days with my forum being slow to load or sometimes hanging and that was the culprit.
Try to use css wherever you can for your styling including turning that on in the vboptions. Any extra JS you use should load with the footer and any extra css files should load with the header, should help speed things up a little.
What a nightmare to set up and admin!
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