I currently use vbPortal at www.swgbounties.com and have been since 2.x. 3.x is currently in beta 2 but there are no major bugs at all. Works beautifully. They are currnetly tweaking the system a bit and adding more features. Overall I think it's by far the best cms out and specifically made to be used with vBulletin.
Yes I also did use vbportal at first. It is a decent cms, especially if you are not able to bridge other management systems. I just found that if you are trying to run a very diverse website with many different types of content that the nuke type cms are much more robust.
To the best of my knowledge, I have not seen any video, audio, shopping cart type of modules for vbportal. There are just so many more features that the nuke cms offer that it was well worth my time to have the applications bridged.
I would say if you are only looking to extend vbulletin with a few extra news type of mods then vbportal does the job great. If you are looking for a huge amount of tools to offer your members, then nothing at this point compares to the nuke type of content management systems.
The integration between the two engines is completelly seamless in our setup. A person who comes does not notice any difference of operation of the two separate systems.
view it live at www.annointed.net