I use it too and it is excellent at what it does. However, it is not a Vbulletin mod and does not integrate so certain tasks you do in ACP or even on the board itself, will trigger a SQL injection attack (among others) block, thread titles that contain wildcard characters too.
That said, you can tune the signature file to suit your needs.
I've simply taken to turning ZB Block off temporarily when I have something that needs doing either in the AdminCP or from a SSH konsole connection that would trigger a false positive. When I'm done, I turn it on again.
Before we installed ZB Block, I was cleaning up spam and spam accounts every day, and the number of such was increasing, and that was, even then, with Spam-O-Matic installed. After installing ZB Block, the number of spam accounts that got registered (and as a consequence, spam posts) went to practically zero. I'm a firm believer in ZB Block. It simply works.