well depends what you like... easy? go with redhat/fedora or something.
configure everything? gentoo, maybe debian
all the latest software & bugfixes? gentoo
afaik red hat is still most widely used as server software
personally i like debian... It's like gentoo, but without compiling every single software pacakage you need...
i can't say anything about user numbers or anything because that depends on too much things, hardware (combination), os, software optimization etc
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