I wish that there was something like this for us. Right now I've got a pretty complex backend all setup that is confusing as hell to setup/edit. But when you're ready to publish a podcast, its easy as pie.
http://www.mlgpwncast.com
Anyhow, I do my editing, add chapters etc. in Garageband 2, make the front page news post, and publish the feed with a really cool utility called "podcast maker" by The Potion Factory.
That's it. Once I get it edited, its as easy as pie - thank the lord :-P.
From there, ArticleBot will automatically grab it and add it to the Episode Library (which I'm going to redo, without a doubt, to make it so much nicer). Then, its over for that show.
Of course, I've got to publish my shownotes separately (actually, I'm writing the Potion Factory about adding a feature to publish PDF shownotes simultaneously).
My single biggest recommendation for anyone who does a podcast? Publish iTunes enhanced shows! Click on E10 of the MLG PwnCast for a great example.
Every single one of my listeners loves it. They can skip around it etc. Simple things like this make your show oh so much better.
Anyhow, I wish that vB had podcast support when I started everything

- life would have been oh so much easier

.