Yes, it is possible, you just have have to do the table settings properly.
For example, the profile fields are not stored in the user table, they are stored inside userfield table. So you'd have to put that for the table name. There where name should be userid, and the where value should be $vbulletin->userinfo['userid']. Then for the Set Name, it would be the name of the field like fieldX, and the Set Value would be what you want to set that field to when someone purchases it. And the Set Type should be String.
That should do it for what you want to do.
-CMX
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