At this time there are no hacks for this, it would be possible. But a lot of hackers think phpnuke is a bit overloaded and not worth it to be integrated. It's been attempted in the past and I do remember quite a few posts about it over on the phpnuke forums.
If you are looking for a close alternative you should check vBportal.com (i think that is the site) they have it based on phpnuke.
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