This is a question that usually belongs to vb.com but i will try to answer anyway.
To start with, leave the hostname set to 'localhost'.
Set the correct databasename.
Make sure you are using the correct MySQL username and password, and that this user has enough permissions on this database.
If you have shell access (SSH/Telnet) you can try connecting to the database from the commandline with 'mysql' using the same information first.
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