vBulletin is quite fast out of the box, you may find that it will use more memory in some cases but this is due to the fact that it queries the datbase less then pior versions.
Optimize hacks are avaiable for a few area's of the code, you may choose to install these if your board shows a need for a speed boost. Rule of thumb is not to modify anything you don't need to modify, if you have a small to mid sized board most of the time speed tweaking won't be needed. Honestly it will depend on many factors the software begin just one of them.
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