tmp folders normally keep temporary files and as such can be emptied when the application(s) are finished using them
Depends what the files / folder are
They may be session files (which can be deleted).
If I check my sites tmp directory, I have:
awstats
bandwidth
etc.....
If you have these kinds of thing, I wouldn't delete them.
Bottom line is you can probably delete some of the stuff, but
use extreme caution ....
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