Well, I think you defintely want to leave "Use Mailqueue System" set to yes. [S]You *could* turn off cron based sending, in which case you'd be going back to the way it worked before (which has obviously worked well enough for you in the past).[/S] (that's wrong - see post below). The cron based sending was originally a mod that got added into the product. In fact the mod page is here:
https://vborg.vbsupport.ru/showthread.php?t=231715 so you can read about what it's supposed to do for you (in a nutshell, it allows you better control over how many emails get sent per hour, which can be important if you do mass mailing and/or your host has a limit on emails per hour).
In any case, if you decide to turn off cron based sending, you should set the batch size back to what it was.