I doubt the name change of the reg file will help much because they get the new file right from your source code but turning on email verification will help for sure.
There are a few other spam mods that work well as well, I use Glowhost, ozzies mod and the SpamHammer one as well. A combo of these should help though you will still see people trying they just won't get in usually.
There are also things that can be done with usergroup permissions to stop spammers who do get in be able to post links, etc. I believe Ozzy has a mod for this as well.
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