Limited space as someone said above and on rare occasions it could be related to spam, check the session table for an insane amount of entries (30k+ records) because once it hits around 30k records the session table is nothing but trouble and you need to truncate the table.
I'm pretty sure the disk space is the factor as Marv mentioned, tracing down the issue before attempting a fix is the best way to go about this though. As the others said upgrade to 4.2.2 in the least as 4.2.3 is still marked as Beta.
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