[tbworld]

Once you create a new section in the "admincp --> section manager", you may assign the new section a new layout.

1.) Pre-create a new section layout via the "admincp -> Layout Manager". This will contain your new or different widgets.
2.) Create new section in the admincp.
3.) Assign content to this new section. (Make sure it is published).
4.) Select your 'Articles' or 'Home' tab and select your new section.
5.) Now select via the 'pencil' and edit the section layout.

Note - On an existing section you can also assign a different layout. Use the 'Pencil' editor on the section page.

This is what @Lynne was referring too, I just expanded it.