You might be able to get around this by going into general settings, and changing the Ajax option to "disable problematic ajax".
We got bumped up to 5.4 for too and it's been a pain, we can't back track, so I've had to live with it. After tweaking the Ajax settings, most of the major issues we were having (editing posts and such) seemed to clear up. Obviously I miss the inline-editing, but it's a small price to pay for now.
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