That would be a BAD idea... content.php already has THIS_SCRIPT defined as:
Code:
define('THIS_SCRIPT', 'vbcms');
Changing it would likely break other mods of even some vbulletin features itself.
Define your own constant, something other than THIS_SCRIPT...
Maybe
Code:
define('IS_HOME', 'yes');
And then in the conditional:
Code:
<vb:if condition="IS_HOME != 'yes'">