Plugins and templates work together to create the page being viewed. I think of plugins kind of as the "back end" and templates more of the "front end."
If a plugin looks for specific data on a template that it will modify (called an automatic template edit) then editing the template and altering that data could well prevent the plugin from working as intended.
If the plugin relies on a template hook to display data on a template then remove the hook would prevent the plugin from working.
But in most cases editing a template does not affect the plugins.
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