Take a backup, move the attachments, see if they moved and everything works (make sure to do a hard refresh on pages you have visited before to get the files served up correctly). If everything is fine, then great. If it isn't, then import your backup.
I really don't know anything about nginx. You tried this once, right? Did you look in your error_logs (if you don't know where they are, ask your host) to see if there was an entry there?
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