<a href="http://www.vbulletin.com/forum/showthread.php?366831-HELP!-Extended-delay-in-thread-re-load-after-post" target="_blank">Here is the thread</a> over on vbulletin.com.
In my instance, it turned out to be a slow response from the mail server. There is a TON of optimizations that eva2000 posted in that thread. While none of it specifically fixed my issue, it did allow exposure of the true problem based on what bit of db query was always in the 'mysql server went away' messages that started after the optimizations.
Re: the mail server, I simply did a 'telnet mailserver 25' and in my instance, it took several seconds to even get the initial 220 mailserver ESMTP response.
Hope this helps!
LK
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