Popular email domains like gmail, hotmail, yahoo, etc could be white-listed. Additional checks can be built in. For example by having a small group of volunteers double-check each throwaway email domain submission. Im sure there are admins/moderators that are willing to do that, as there will not be that many new domains a month.
Another reason for this suggestion is bouncing email. If your users can sign up with fake email, then this will cause a mass of bounces to be sent to your server.
Bouncing email can cause your site to be listed as a spammer. Its bizarre but true.
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