Hi There,
A few things in my experience can slow a forum down. Now it should be noted I do not own Vbulletin 4 and my knowledge of its internal workings is slim but I think that some of what I have to say will still fit.
Everything you said does play a roll in slowing your forum down, I would suggest setting smaller limits on all 3. When it comes to attachments, threads etc I would suggest you that you repair/optimize your database tables. The option can be found in Admin CP > Repair / Optimize Tables
Also just thought of this how many mods do you have installed as these will add more load on the server and database.
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