Look in your error_logs (if you don't know where they are, ask your host) to see if there is a clue in there.
Try disabling your modifications/plugins and see if you still have this problem.
Note: To temporarily disable the plugin system, edit config.php and add this line right under <?php
PHP Code:
define('DISABLE_HOOKS', true);
Don't forget that for vbseo, disabling the modification means to also get rid of anything extra you added to your htaccess file.