I wrote this plugin for someone who wanted to do something like this on the member.php page. I'm sure you can modify it for use in the postbit (use one of the postbit_ hook locations - and change the field id, of course):
PHP Code:
if ($profilefield['profilefieldid'] == 16)
{
$find = ",";
$replace = "<br />";
$profilefield['value']= str_replace($find, $replace, $profilefield['value']);
}