1. Yes, you should close your board down. This will prevent locking of tables that are still in use.
2. If the difference between versions is great, uninstall the modification and upgrade with the most up-to-date version provided the version you are upgrading to is meant for the version of vBulletin. In most cases, you can just leave the modification installed and it will either work or don't work. Check with each modification to ensure that there won't be any compatibility issues.
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