HI Herwaarden,
i asked the same question about duplicate posting in another vbulletin forum and one of supporter advised me to follow these steps.....
1) I have seen double posting problems caused by not having a flood check:
Admin CP -> vBulletin Options -> Message Posting and Editing Options -> Minimum Time Between Posts
Make sure this is not set to 0.
2) You might also try disabling the problematic AJAX features (which includes the quick reply):
Admin CP -> vBulletin Options -> General Settings -> Disable AJAX Features
3) Email notifications can also cause delays when posting if the mail server is being slow. Try disabling email features to test this:
Admin CP -> vBulletin Options -> Email Options -> Enable Email features?
Now i have follwed these steps and it seems like my users are not getting duplicate since i made above mentioned changes.
I asked him how to fix it, his reply was.....
AJAX is the most probable cause. When your connection is laggy or unreliable then AJAX posting can result in double posts
Obviously i cant leave these settings like this, so could you please tell me how do i fix it. i want to know your views before i open a support ticket.
Thanks In Advance

Have fun...!