Here is how I got my Adobe Reader 8.1.2 to read a secure PDF outloud under Windows Vista...
1) Went to Start -> All Programs -> Accessories -> Ease of Access -> Navigator
2) Adobe Reader opened the Accessibility setup wizard which I went through. When done, it downloaded a small update and installed it.
3) With my secure PDF opened, I choose View -> Read Out Loud -> Activate Read Outloud.
4) Clicked on the paragraph where I wanted it to start reading. CTRL-SHIFT-B will tell it to read the entire document.
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