I do a comic on my site (however infrequent) based around a comic shop and TCG players. It got some marginally good reviews.
Pwnd!
If I where to make a suggestion, I'd suggest taking a cue from Dave Chappelle. He had a skit on his show where he asked: What would the internet be like if it where an actual place that you visited? I think a great comic that would lend it self to good humor would be one that asks: What if vBulletin.com where an actual place that you could visit?
Just imagine what someone showing up as unlicensed would look like? What happens to a real person when his topic gets locked. Do trolls look like actual trolls? Is everyone's avatar is a patch or symbol on their t-shirts? Does the staff all dress like they do at Best Buy? Do Coders dress like the Geek Squad? I see some endless possibilities here.