Running a repair/optimise on the database is not necessary and really shouldn't be run unless you need to.
If you have mod_gzip (Apache 1.x) or mod_deflate (Apache 2.x) installed, do not enabled GZIP compression inside vBulletin's Admin CP - this leads to "double processing". If you don't however, you should enable it and set the compression level to 1, any more will waste CPU cycles.
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