<a href="http://uk.php.net/register_globals" target="_blank">Using Register Globals</a> Have a read of the first two paragraphs, you shouldn't leave it on really.
Just Google "register_globals" and you'll find out more information about it and why it should be left on. vBulletin doesn't rely on it so if thats all you are running on it then you can just leave it off.
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