you move all existing users with more than 1 post to a usergroup called registered promoted or what ever you want. then set up the registered usergroup with limited permissions and to be monitored by akismet. Make it so they have to make like 5 posts to be promoted to the second usergroup.
This will contain your spam sign ups, monitor them and give them reduced privileges such as not b3eing able to edit their posts, or having reduced number of PM's etc.
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