I'd start with Modify User Options Templates >> modifyavatar
The code for the submit button should look like:
Code:
<input type="submit" class="button" value="$vbphrase[save_changes]" accesskey="s" />
If the information is simply being cleared out when you intend to save, some of the content in the code may look more like this, which is the reset button:
Code:
<input type="reset" class="button" value="$vbphrase[reset_fields]" accesskey="r" />
The default vB design includes both options, as shown below:
Code:
<input type="submit" class="button" value="$vbphrase[save_changes]" accesskey="s" />
<input type="reset" class="button" value="$vbphrase[reset_fields]" accesskey="r" />
That would be my initial guess for what the problem could be, but it's still possible that something else is wrong in the code.