Make sure that you have uploaded all the vBulletin folder to your server. Please go to via FTP, log in and make sure you have all 10 folders uploaded.
NOTE: If you have all 10 folder, make sure your folder customavatars is set to 777 and customprofilespic is set to 777
OR
ACP>Avatars>User Picture Storage Type
Avatar File Path
This file path should be readable AND writeable by your web server (usually chmod 0777)
URL to avatars
(Relative to your forums home page)
Profile Picture Path
This file path should be readable AND writeable by your web server (usually chmod 0777)
Code:
./customprofilepics
URL to Profile Pictures
(Relative to your forums home page)
The text inside the code is what you're suppose to have.