The most important factor when creating a site is the subject and content. You can (and some do) modify it till you are blue in the face, but without a decent content it will never actually go anywhere.
If you have a good subject for your site, and can start injecting content into it, then this is the most important place to start. Some modifications can enhance the experience for your users, but others can completely take away from it, it all depends on the content and what is appropraite for that sector.
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